Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems.
نویسندگان
چکیده
A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 20 شماره
صفحات -
تاریخ انتشار 2010